362 -Cannabidiol (CBD) and Mental Health
Counselor Toolbox

00:00 / 56:44

Cannabidiol: Mental Health Uses and Cautions

The CEU/OPD/CPD course can be found at https://allceus.com/member/cart/index/product/id/982/c/ for clinicians in the US and at https://australia.allceus.com/member/cart/index/product/id/516/c/ for clinicians in Australia.

Intro to CBD
~ THC is the psychoactive component of cannabis
~ THC has antispasmodic, analgesic, anti-tremor, anti-inflammatory, appetite stimulating and anti-emetic properties
~ High levels of THC is commonly used for its sleep-inducing effects
~ THC mimics the effects of anandamide and 2-AG (endogenous cannabinoid) which modulates sleeping and eating habits, the perception of pain
~ GABA neurons contain CBD receptors which are activated upon useof THC (and maybe CBD) https://www.royalqueenseeds.com/blog-the-link-between-marijuana-and-dopamine-n823

CBD cont…
~ CBD is the major nonpsychoactive component of Cannabis sativa.
~ According to a 2013 study published in the British Journal of Clinical Pharmacology, CBD benefits include acting as an anti-inflammatory, anticonvulsant, antioxidant, antiemetic, anxiolytic, neuroprotective, immunomodulatory and antipsychotic effects
~ A biphasic drug has different effects on the body at different blood concentration levels.
~ Ex. Alcohol acts as a stimulant until BAC levels reach 0.05%. After this point it causes sedation and depression
~ At a low concentration CBD increases wakefulness, alertness and other elevating responses.
~ At higher levels CBD has a sedating effect

CBD cont…
~ 36% of respondents reported that CBD treats their medical condition(s) “very well by itself,” while only 4.3% reported “not very well.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6043845/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/

The Cannabinoid Receptors
~ CBD and THC both bind to the CB 1 & 2 receptors, they interact with them different ways
~ CB1 and CB2 are both responsible for regulating neuro-hormones which are involved in memory, mood, sensations of pain and appetite regulation
~ CB1
~ Found in the CNS and responds to endogenous cannabinoids, as well as THC (agonist) and CBD (mild antagonist).
~ Abundant in areas of the brain concerned with movement, coordination, pain and sensory perception, emotion, memory, cognition, autonomic and endocrine (hormone) functions
The Cannabinoid Receptors
~ CB2
~ Found only in the immune system and not in the CNS, but seems to reduce inflammation and related pain.
~ It responds to endogenous cannabinoids, as well as CBD, THC
Alcohol and CBD

~ The CB1 receptor is a significant player in the reinforcing and motivating attributes of alcohol. Combining alcohol and CBD results in significantly lower blood levels of alcohol.
~ CBD reduces the reinforcement, motivation and relapse for alcohol.
~ CBD attenuates alcohol-induced liver steatosis, metabolic dysregulation, inflammation and neutrophil-mediated injury.
~ Cannabinoids have an effect on nearly all enzymes responsible for metabolizing alcohol.
~ Cannabinoid antagonists also mitigate alcohol withdrawal symptoms.
~ CB1 receptor agonists (THC) encourage alcohol consumption, while CB1 receptor antagonists (CBD) decrease it.

Benefits of CBD
~ According to the National Institute of Health, manipulating the endocannabinoid system by introducing external cannabinoids like CBD could be useful in treating a variety of medical ailments, including:
How CBD Impacts Mood
~ CBD can help people recover from Clostridium difficile toxin A toxicity and restore the intestinal barrier* https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721977/
~ CBD reduces chronic pain https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2503660/
~ CBD binds with estrogen receptors https://www.ncbi.nlm.nih.gov/pubmed/6296360
~ Impacts insulin levels via cannabinoid receptors in the pancreas http://www.cbdforbenefits.com/top-3-ways-cbd-oil-balances-estrogen-levels/
~ 160mg-600mg of cannabidiol may play a therapeutic role in sleep regulation, increase in sleep time and reduced awakenings (Monti, 1977; Chagas et al., 2014b, Zuardi et al., 1993, Carlini and Cunha, 1981).
~ The endocannabinoid system plays a significant role in regulation of the HPA-Axis and reduces cortisol production https://www.ncbi.nlm.nih.gov/pubmed/30036537, https://www.ncbi.nlm.nih.gov/pubmed/18426497

CBD and Neurotransmitters
~ The activation of adenosine receptors by CBD
~ Produces anti-anxiety and anti-inflammatory effects of cannabidiol.
~ Release of dopamine and glutamate, two neurotransmitters that play major roles inside the body.
~ Dopamine is involved in cognition, motor control, motivation and reward mechanisms
~ Glutamate is one of the main excitatory neurotransmitters, being involved in memory, learning and cognition.
~ Higher concentrations of CBD have been shown to activate the 5-HT1A serotonin receptor, impacting pain, sleep and mood

CBD and Neurotransmitters
~ Using marijuana or CBD while on antidepressants or antipsychotics can be potentially dangerous, as it can intensify any or all of the effects, making a patient's condition even worse. (This is also very similar with sedatives and alcohol)
~ https://www.ncbi.nlm.nih.gov/pubmed/22716160
~ https://www.ncbi.nlm.nih.gov/pubmed/22729452
~ Overview of CBD Safety: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5569602/

CBD and Parkinson’s Disease
~ PD is associated with impairment of motor control after the loss of 60-80% of dopamine-producing neurons
~ The endocannabinoid system plays a major role in Parkinson’s Disease.
~ CBD boosts dopamine levels in preclinical studies…but
~ Long-term, heavy marijuana usage could reduce dopamine levels
~ Digestive imbalance (sick gut) may play a role in the advancement of PD & the severity of symptoms.
~ Cannabinoids have neuroprotectant, anti-oxidant and anti-inflammatory properties which can be beneficial for managing PD.
Drugs that Interact with CBD
~ Any drug metabolized by CYP450 enzymes could potentially interact with cannabidiol. According to the Indiana University Department of Medicine, drugs known to use the CYP450 system include:

Increasing Natural Cannabinoids
~ In order to produce the proper amount of endogenous cannabinoids, the body requires a sufficient amount of Omega-3 fatty acids the pre cursor to endogenous cannabinoids
~ Hemp seeds and hemp oil
~ Chia seeds
~ Walnuts
~ Fatty fish
~ Eggs (pasture-fed or omega-3 enriched only)
~ Cacao powder contains three compounds that are structurally very similar to endocannabinoids and inhibit the breakdown of endocannabinoids. (70-90% dark chocolate) di Tomaso, Emmanuelle. “Brain cannabinoids in chocolate.” Nature 382 (1996): 677-678.

Increasing Natural Cannabinoids
~ Beta-caryophyllene is found in black pepper, lemon balm, hops, cloves, cannabis, oregano, cinnamon and stimulates the CB2 receptor (immune/anti-inflammatory)
~ Echinacea also contains CB2 agonists according to Dustin Sulak, DO
~ Kava may stimulate the CB1 receptor
~ Black and Green tea prevents the breakdown of endocannabinoids, and stimulate cannabinoid receptors. Thors L, Burston JJ, Alter BJ, McKinney MK, Cravatt BF, et al. (2010) Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase. British Journal of Pharmacology 160: 549–560.
~ Lactobacillus acidophilus activates CBT recpetors
~ Studies show that DIM reduces inflammation by binding to CB2 receptors
~ Curcumin (found in turmeric) raises endocannabinoid. Hassanzadeh P, Hassanzadeh A (2012) The CB1 receptor-mediated endocannabinoid signaling and NGF: the novel targets of curcumin. Neurochemical Research 37: 1112–1120.
~ https://www.optimallivingdynamics.com/blog/how-to-stimulate-and-support-your-endocannabinoid-system

CBD Oil Dosing
~ The FDA has not created a Recommended Daily Intake (RDI) for CBD, which means CBD does not have an official serving size nor is it formally regulated.
~ CBD impacts are affected by body weight, body fat percentage, and other hormonal and physiological processes.
~ With that being said, a good rule of thumb is 1–6MG of CBD for every 10 pounds of body weight to start. https://medium.com/cbd-origin/whats-the-best-cbd-dosage-81ec4f95503b
~ Cannabidiol comes in
~ Oil
~ Tincture
~ Vape
~ Capsules
~ Topicals
~ Suppositories
~ Cannabidiol is the non-euphoric cannabinoid.
~ THC is the cannabinoid which produces the euphoric effects.
~ The endocannabinoid system is highly connected with
~ Sleep
~ Inflammation
~ Mood (serotonin, dopamine, glutamate)
~ Sex hormones (esp. estrogen)
~ Muscle coordination
~ Significant research has shown the benefits of cannabidiol for everything from anxiety to inflammation and psychosis.
~ It is important to note that CBD and THC can interact with most medications so medical supervision is strongly advised.
~ Natural methods to enhance the ECS include omega-3s, curcumin, black and green tea, black pepper, cinnamon, kava and echinacea

By continuing to use the site, you agree to the use of cookies. more information

The cookie settings on this website are set to "allow cookies" to give you the best browsing experience possible. If you continue to use this website without changing your cookie settings or you click "Accept" below then you are consenting to this.